Rejuran is an innovative skin rejuvenation treatment made from polynucleotides (PN) derived from salmon DNA, designed to repair the skin at a cellular level. While the active ingredient is the same, the delivery method significantly impacts your comfort, recovery, and final results.
In this guide, we’ll compare the three Rejuran delivery techniques — microinjections, blunt cannula, and microneedling — to help you understand which method may be best suited to your skin concerns, treatment goals, and downtime preferences.
Why does the delivery method matter?
The delivery technique determines:
- Depth of penetration
- Distribution of product
- Level of discomfort
- Downtime and bruising risk
- Effectiveness for different treatment areas
Even though the product is the same, choosing the right delivery method can optimise outcomes.
1. Rejuran microinjections
What it is
Tiny amounts of Rejuran are injected directly into the dermis using a fine needle. This is the traditional and most widely used method.
Best for
- Fine lines
- Under-eye crepiness
- Full-face rejuvenation
- Targeted areas needing collagen stimulation like acne scars
Pros
- Very precise placement
- Strong cellular renewal effects
- Ideal for areas that require precise delivery delicate areas (eyes, lips)
Cons
- Visible bumps for 24–48 hours
- Discomfort during treatment
- Higher chance of pinpoint bruising
- Product loss, as some Rejuran often flows back out through the injection site
Downtime
- Small raised bumps (papules) may be visible for 24 hours
- Mild redness or swelling settles within 24 hours
2. Rejuran via blunt cannula
What it is
A blunt-tipped cannula is inserted through a single entry point to distribute Rejuran beneath the skin in a fanning motion. Instead of multiple injections, the product is gently layered under the dermis through a single entry point per area.
Best for
- Larger treatment areas such as cheeks, jawline, neck
- Patients wanting minimal needle entry points
- Those prone to bruising
Pros
- Fewer needle punctures
- Reduced downtime and swelling
- Avoids injection-related pain
- Lower risk of bruising and vascular injury
- Efficient use of product–the entire syringe will be injected
Cons
- Less precise for very superficial lines or under-eye crepiness
- Requires an experienced injector for even distribution
Downtime
- Mild swelling possible but usually no visible bumps
- Most patients return to normal activities immediately
3. Rejuran with microneedling
What it is
Microneedling creates controlled microchannels in the skin. Clinicians then apply Rejuran topically, with the aim of allowing it to infuse the the microchannels.
Best for
- Budget conscious people who are looking for the most cost-effective option
Pros
- Provides both benefits from Rejuran and microneedling
- More affordable because it can be performed by non-medical skin therapists
Cons
- Far less product absorption than other methods (most is left on the skin’s surface)
- Has the risks of microneedling
Downtime
- Mild redness for 12–24 hours
- Feels similar to a light sunburn temporarily
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Treatment method comparison
Precision:
- Microinjections – Allows exact deposit at specific points or lines, making it ideal for under eyes and targeted rejuvenation.
- Cannula – Good precision for broader areas, but less exact placement compared to microinjections.
- Microneedling – Poor precision because product is applied to the surface and absorbed through channels. This leads to less controlled delivery depth and product wastage.
Downtime & visibility after treatment:
- Microinjections – Visible bumps, redness, swelling, and potential bruising for 1-3 days.
- Microneedling – Diffuse redness and swelling for 1-3 days.
- Cannula (Fastest recovery) – Minimal swelling, no visible bumps, lowest risk of bruising.
It’s helpful to understand what to expect after getting Rejuran, regardless of the delivery method.
Comfort:
- Microinjections (Least comfortable) – Multiple punctures and injection into the dermis is uncomfortable, even with numbing.
- Microneedling – Moderate prolonged discomfort as treatment takes longer than other methods. Most clinics using this method do not have access to proper numbing options.
- Cannula (Most comfortable) – Only 1-2 entry points per side, very little discomfort even without numbing.
Worrying about pain is an understandable concern people have about Rejuran. Fortunately, we can minimise pain from Rejraun with the right techniques and numbing.
Best for:
- Microinjections – Fine lines, under eyes, targeted rejuvenation
- Cannula – Full face, neck, jawline, patients wanting low downtime or treatments with little discomfort
- Microneedling – People who are budget conscious and want a more affordable option, however results are sub-par due to inaccurate & inefficient delivery
Treatment time:
- Microinjections – 10-15 minutes per side per area, up to 45 minutes for a full face treatment.
- Cannula – Less than 5 minutes per area for both sides.
- Microneedling – Typically 30 minutes of microneedling.
Depth of delivery
- Microinjections (Deep dermal delivery) – Direct placement into the optimal collagen-stimulating layer.
- Blunt cannula – Subdermal spread stimulates collagen across a broader plane and slightly deeper than microinjections.
- Microneedling – Upper dermis only, limiting the intensity of rejuvenation.
Overall outcome
- Microinjections (Most intensive results) – Strong cellular renewal and visible skin quality optimisation. However, most people often fail to complete the required number of treatment sessions because of the associated pain.
- Blunt cannula – Balanced results with minimal downtime and maximal comfort; ideal for consistent skin rejuvenation. While not as effective as microinjections, because it is well tolerated, people are more willing to commit to proper treatment schedules, meaning the end result is superior.
- Microneedling – Improves surface texture gradually; but likely the result of microneedling rather than Rejuran due to inaccurate delivery and extensive product wastage.
Which Rejuran delivery is right for you?
Rejuran is only as effective as the way it’s delivered. However comfort is the most critical consideration, because if it’s too painful, you won’t proceed with additional treatments if you need them. Whether you need precision, widespread cellular renewal or minimal downtime, your clinician will select the best method — or combination of methods — to meet your skin goals. Often, the best method depends on the reasons for getting Rejuran treatment.
Understanding what happens during a Rejuran session step-by-step is also a key thing to know prior to proceeding.
Want to know more about Rejuran?
Learn more about Rejuran treatments in our complete Rejuran treatment guide.
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