Rejuran I PDRN injections
Convenient, efficient appointments
Non-surgical, in-office procedure
Tailored to your skin's needs
Doctor-led care and ongoing support
All-inclusive pricing available
Target skin regeneration and dermal quality for smoother texture and refined tone.
As collagen production slows with ageing and environmental stress, skin repair becomes less efficient. Once resilient skin may begin to look dull, crepey, uneven, and tired.
Rejuran treatments may support skin renewal from within, improving skin integrity and quality.
Start your booking process by providing us some details
As seen in
When skincare stops being enough
Improve skin quality with preventative therapy.
Personalised, Professional Treatment
Rejuvenate your skin with a personalised Rejuran treatment, tailored by product type, dose, and delivery technique to match your needs.
Reducing Discomfort & Downtime
We use various approaches to reduce discomfort and avoid post-treatment lumps.
Treatment info
Treatment objectives
Suitability
Preparation
Aftercare
Results
Why people trust Cosmetic Connection
We move beyond “beauty retail” to provide a doctor-led environment.
Our focus is on thoughtful, measured assessments, and calculated clinical plans, ensuring your treatment is guided by medical expertise.
Identify your suitability before you commit to a treatment.
Our process evaluates your anatomical baseline, providing clarity that replaces the risk of a vague “discovery session”.
We replace guesswork with calculation.
By applying our 3-Pillar Framework (Anatomy, Aetiology (cause), Goals), we ensure every treatment is clinically appropriate and structurally sound.
To maintain integrity, we removed the incentive for over-treatment.
Our transparent flat-fee pricing ensures your clinician is focussed purely on your result, not the amount of product.
By applying the 90/10 Rule of Restraint, we refine your appearance while protecting your natural character.
Your result looks like you, not like you had a treatment.
What Rejuran is & how it works
Rejuran is a regenerative skin treatment designed to improve the quality and function of your skin at a cellular level. Unlike treatments that add volume or reduce expression wrinkles, Rejuran works by supporting the skin’s natural ability to repair itself. It is classified as a bio-regenerative treatment, focused on long-term skin health rather than temporary cosmetic enhancement.
The active ingredient in Rejuran is polynucleotide (PN) — purified DNA fragments derived from salmon. These DNA fragments are biocompatible with human skin and are used by skin cells to support repair, improve hydration, and maintain optimal function. When injected into the dermis, Rejuran creates a restorative environment that encourages your skin to regenerate from within.
How it supports skin health
- Cellular repair: Polynucleotides act as building blocks that damaged or ageing skin cells can use to repair themselves.
- Collagen production: Rejuran is thought to stimulate fibroblasts – the cells responsible for producing collagen – helping to improve firmness and structure over time.
- Improved skin environment: The treatment may enhance hydration and supports the extracellular matrix, allowing the skin to function more efficiently and resist external stressors.
A regenerative, not cosmetic treatment
Rejuran does not change the shape of your face or provide instant visible results. Instead, it works gradually to improve the biological health of your skin, enhancing its texture, elasticity, and resilience. Many people describe the results as “strengthened, balanced, and healthier-feeling skin” rather than a visual change.
While research is ongoing and the exact biological mechanisms are not yet fully understood, clinical use and emerging studies show Rejuran to be a safe, low-risk option for investing in skin rejuvenation and supporting overall skin longevity.
Where Rejuran can be used & who it’s best for
Rejuran is suitable for people who want to improve the quality and function of their skin, especially in areas where the skin is thin, delicate, or showing early signs of ageing. It is not designed to change facial features, add volume, or strongly target wrinkles. Instead, it restores balance, hydration, elasticity, and resilience in the skin from within.
Rejuran may be suitable if you:
- Want to address skin fragility, roughness, or early fine lines
- Are looking to prevent age-related skin changes
- Have textural concerns such as enlarged pores or mild scarring
- Wish to improve under-eye skin where other treatments may not be suitable
- Prefer regenerative, subtle results rather than cosmetic alteration
It can be used as a standalone treatment for prevention and skin strengthening, or alongside other treatments such as active skin care, collagen stimulators, skin hydration treatments, or facial volumisers as part of a long-term skin maintenance plan.
Key treatment areas
Under eyes
The under-eye area is often the first to show signs of ageing due to thin skin and reduced collagen. Rejuran supports skin healing and improves texture, making it an option for people with:
- Crepey texture
- Early fine lines
- Mild hollowing due to skin thinning (not volume loss)
- Tired or dull-looking skin
Patients often report the skin feeling stronger and smoother rather than seeing visual differences.
Full face rejuvenation
When used across the face, Rejuran is intended to improve overall skin quality. It may support:
- Balanced hydration
- More resilient texture
- Improved ability of the skin to tolerate environmental stressors
This can be beneficial for people experiencing early ageing-related skin changes, sensitivity, or naturally delicate skin.
Lips
Rejuran is not a lip filler. It does not add volume. Instead, it can be used with the goal of improving:
- Lip hydration
- Fine lines on and around the lips
- Skin integrity in those with chronically dry or ageing lips
Patients often describe their lips as feeling smoother and more moisturised.
Neck, chest (décolletage) and hands
These areas are prone to premature ageing due to sun exposure and reduced collagen. Rejuran may help support:
- Skin elasticity
- Fine creases and rough texture
- Long-term skin preservation
Acne scarring, surgical scars and textural concerns
Rejuran may be used to support skin healing in areas affected by previous inflammation or scarring. It does not “fill” scars but may improve the surrounding skin quality by supporting regeneration and collagen production.
Evidence shows that Rejuran is best used during the healing phase of scars in combination with other methods, rather than in isolation or on old, mature ones.
Who can benefit?
Rejuran is an option for:
- People in their late 20s and beyond looking to prevent visible ageing
- Those in their 30s–50s wanting to address early signs of ageing without volume changes
- Individuals with thin, fragile, or sensitive skin
- Patients who have already had other treatments and want to focus on strengthening the skin itself to optimise results
Rejuran is not a cosmetic contouring treatment — it is best suited to individuals focused on long-term skin health, cellular repair, and prevention, and works best when used in conjunction with good skin care and a healthy lifestyle.
Rejuran results: What to expect
Rejuran aims to improve the function and health of your skin at a cellular level. Its results are gradual and primarily felt before they are seen. Changes develop over time as the skin repairs, regenerates, and becomes more resilient.
How results develop
- Changes build progressively with each session.
- Most people begin to feel their skin changing before noticing visible effects—skin may feel stronger, smoother, more hydrated, and better able to retain moisture.
- Visible results, when they occur, are subtle and natural. Rather than altering facial shape, Rejuran helps the skin appear healthier, calmer, and more refined.
What you may notice
Patients commonly report:
- Improved skin texture and softness
- Better hydration and reduced dryness
- Less crepiness in delicate areas (such as under the eyes or lips)
- A gradual reduction in fine textural lines
Some patients describe their skin as more resilient to irritation and environmental stressors.
Rejuran is a long-term investment in skin health
Results are not designed to be dramatic or immediate. Instead, Rejuran focuses on longevity and cellular optimisation. It is often used as part of a preventative or maintenance plan alongside other treatments.
Treatment course and longevity
- A series of sessions is usually required to initiate the regenerative response (typically 3 sessions, spaced 4 weeks apart for most concerns).
- Maintenance treatments may be recommended every 6–12 months, depending on your skin’s needs.
- The duration of benefits varies between individuals and is influenced by factors such as lifestyle, metabolism, and the area treated.
Over time, the effects gradually diminish as the skin continues to age. To maintain optimal skin health with Rejuran, periodic treatment is required.
What Rejuran does not do
To set clear expectations:
- It does not add volume or physically lift the skin
- It does not significantly reduce wrinkles
- Changes are gradual, not instant, and more preventative in nature
- Most of the result is in how your skin feels and functions, not in visible transformation
TL;DR
Rejuran is best thought of as a regenerative treatment that aims to improve the quality, health, and longevity of your skin. It supports long-term skin integrity rather than offering a quick cosmetic change. For people focused on future-proofing their skin and optimising its natural resilience, Rejuran is an option to consider.
Have questions?
Read the FAQ below for general information. For personalised advice, start here.
Rejuran is an injectable product used for skin rejuvenation made of salmon polynucleotide DNA fragments.
It consists of bio-active DNA molecules known as polynucleotides that stimulate fibroblasts to make the skins environment more favourable for cellular function.
Rejuran aims to increase the activity of fibroblast cells, promoting long-term elastin and collagen growth in the skin.
In doing so, it aims to reduce inflammation, smooth skin texture, increase elasticity and hydration, balance tone and pigmentation, and reduce fine lines, oil production, pore size, and acne or surgical scars.
Rejuran is an injectable polynucleotide product, that works by stimulating fibroblast cells.
While it can be used to treat texture wrinkles, there are other methods that target fine lines more effectively.
Rejuran is not the same thing as filler.
Rejuran are polynucleotide gels that aim to stimulate cellular renewal and collagen synthesis in the skin.
Polynucleotides are slow-degrading DNA fragments. In the case of Rejuran, they are derived from salmon sperm.
Most patients require 3-4 sessions space 4 weeks apart, but this depends on your specific needs.
Repeat treatments are required once every 6-12 months if you wish to maintain the benefits.
We provide transparent pricing for Rejuran, with the final cost depending on your individual needs. This includes the type of Rejuran, the amount used, and the number of sessions required.
For multi-session treatments, we have packages available to make your treatment more cost effective.
Yes, depending on your concerns and suitability, Rejuran can be combined with other treatments, such as wrinkle treatments, collagen stimulators, and serums. It’s often used as part of a long-term skin health plan.
The amount of Rejuran required for your treatment depends on the area, and specific concerns. Average volumes of Rejuran based on area are:
- 1-2 mL around the eyes
- 1mL for the lips
- 3-4 mL for full face treatments
- 2 mL for the neck
You will need to remove your makeup before arriving at your appointment.
Initial clinical photos are taken, and numbing gel may be applied to the treatment area.
The treatment area is then numbed for comfort.
Once numb, Rejuran is placed precisely into the skin, using either tiny needles, or a blunt cannula.
Rejuran treatments typically take 5-30 minutes depending on the treatment area, and the chosen injection method.
Discomfort with Rejuran depends on a range of factors.
While it is known to be an uncomfortable treatment when performed the traditional way, there are now a range of methods to reduce pain during Rejuran treatments.
Results develop gradually. Patients often notice their skin feeling more hydrated, smoother, and resilient. Visible changes are more variable, because Rejuran is more about skin quality and health, rather than surface level appearance.
The effects from Rejuran slowly fade over months to years, with specific longevity varying from person to person, and depending on the extent of your treatment.
Most activities can be resumed immediately after a Rejuran treatment, though it’s important to keep your skin clean and avoid applying makeup for the first 24 hours.
Your clinician will also provide personalised guidance on any other activity restrictions based on your individual circumstances.
After Rejuran, you will notice slight redness. If your treatment was done with microinjections, a series of small lumps will be visible for about 24 hours.
Rejuran is not recommended for people with allergies to salmon.
Preliminary studies show that salmon DNA/polynucleotide injections are safe and well tolerated.
Common side effects of Rejuran include slight redness and tenderness.
Rare risks include allergic reactions or infections.
