Rejuran side effects: What to expect before, during, and after treatment

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Rejuran is a popular skin rejuvenation treatment that works at a cellular level to optimise skin texture, elasticity, and overall quality. Like any medical procedure, it can have side effects and risks. Understanding these can help you prepare, set realistic expectations, and recover smoothly.

Common side effects

Most people tolerate Rejuran treatments well. Common, temporary effects include:

  • Redness at injection sites
  • Swelling or mild puffiness immediately after treatment
  • Small lumps or bumps under the skin, which usually resolve within 12–36 hours (with microinjection techniques)
  • Mild bruising around the treated area

These effects are part of the the normal Rejuran recovery phase, and self-resolve in a few days.

Less common side effects

Although rare, some patients may experience:

  • Prolonged swelling or lumps, especially when treating delicate areas with a thicker formulation.
  • Itching or tenderness at the injection sites
  • Allergic reactions, particularly in those with known sensitivities to fish or salmon-derived products (although treatment should be avoided in such individuals), which may range from mild, to severe in rare cases.

These reactions are uncommon and usually resolve with proper aftercare and medical treatment.

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Rejuran I side effects (Under-eye treatment)

Rejuran I (Eye) is specifically formulated for the delicate under-eye area. While it is gentler than other formulations, general side effects are the same for all types of Rejuran, although swelling and lumps may take longer to subside.

Managing side effects & optimising healing

Many treatment related effects like swelling, redness and lumps can be minimised or avoided by choosing the right Rejuran injection technique.

To minimise discomfort and side effects and speed up healing, you can follow the detailed Rejuran aftercare instructions, some of which include:

  • Apply cold compresses to reduce swelling
  • Avoid strenuous exercise, heat exposure, or alcohol for 24–48 hours

Practitioners may advise an additional aftercare measures depending on your needs. Most patients recover quickly and can resume normal activities within a day.

Safety considerations

Rejuran is generally considered safe when administered by a trained medical professional. Choosing an experienced provider reduces the risk of complications. Patients should disclose their medical history, allergies, and current medications with their clinician before treatment to ensure safety.

If you are worried about a side effect from Rejuran, you should contact your treating clinician/clinic immediately, or seek urgent medical attention for serious concerns.

Want to know more about Rejuran?

Learn more about Rejuran treatments in our complete Rejuran treatment guide.

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Rejuran skin rejuvenation

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