Rejuran is known for its regenerative properties, but like any injectable treatment, it comes with a recovery period. Understanding what to expect day by day helps you plan ahead, minimise downtime, and get the best possible results.
This guide breaks down the exact Rejuran healing timeline, what is normal, when to seek advice, and how recovery varies based on the area and treatment technique.
How long is the downtime after Rejuran?
Most people experience visible injection bumps and redness for 12–24 hours, with full surface recovery within 3–4 days. The skin continues to regenerate beneath the surface for weeks as collagen production increases.
- Visible signs (lumps, redness): 1–2 days
- Mild swelling & bruising: 3–5 days
- Internal regeneration: Continues for 4–12 weeks
- Final results: Usually visible at 4–6 weeks after the final session
Day-by-day recovery timeline
Day 0 (Immediately after treatment)
Immediately after your Rejuran treatment, you will see small, raised bumps at each injection site when microinjection techniques are used. These are expected and indicate that the product has been correctly placed in the superficial dermis, where it begins stimulating collagen and skin repair. These bumps typically flatten within a few hours; however, under-eye injections may take up to 24 hours to settle due to the delicate nature of the skin in this area. If Rejuran has been placed with a cannula, there won’t be any lumps.
Mild swelling, redness and a sensation of tightness is also normal. These are not signs of irritation but part of the skin’s controlled inflammatory response, which is necessary for Rejuran to activate its regenerative effects.
Normal and expected responses on Day 0 include:
- Visible microinjection bumps that slowly flatten as Rejuran disperses (when microinjection techniques were used)
- Mild redness and swelling, particularly under the eyes and cheeks
- A firm sensation in the treated area
- Slight bruising in some individuals, depending on skin sensitivity or injection depth
What you should do on Day 0:
- Avoid touching, rubbing or applying pressure to the treated area
- Do not vigorously exercise, drink alcohol, or expose your skin to heat (saunas, hot showers, direct sun) for 1-2 days
If recommended by your clinician, apply cool compresses with light pressure to minimise swelling and soothe the skin
These effects are temporary and indicate that the treatment is active. The majority of patients can resume normal activities immediately, with visible signs typically improving significantly by the next day.
Day 1
- Injection bumps fade slowly in cases when microinjection techniques are used.
- If a blunt cannula technique was used, bumps are absent, but you may have mild swelling or tenderness at entry points.
There are important differences in the treatment efficacy, risk, and recovery between microinjection and blunt cannula Rejuran techniques.
Day 2–3
- Skin may feel slightly dry due to local swelling and mild inflammation.
- Mild deep bruising can appear, particularly under the eyes, and often looks slightly yellow.
Day 4–7
- Surface recovery is mostly complete.
- You may begin to notice subtle improvements in glow and hydration.
Week 2–4
- Collagen stimulation is underway.
- Improvements in texture, elasticity, and firmness emerge.
Week 4–6
- Full results develop, and repeat treatments can be considered if suitable.
- Scarring, pigmentation, and under-eye crepiness improve.
What does Rejuran recovery feel like?
Most people describe the recovery as mild and manageable. You may feel:
- A sensation of tightness or fullness under the skin
- Slight tenderness when pressing on treated areas
- Temporary dryness as the skin heals
These effects are a normal sign that the biological healing response has begun.
Are side effects normal during Rejuran downtime?
Temporary effects such as swelling, redness, and bumps are expected, however there are side effects which are not normal and require medical attention. For a detailed breakdown of potential risks and when to contact your provider, read our guide on Rejuran side effects.
How recovery differs by treatment area
Under eyes:
Downtime is slightly longer due to the thin, delicate skin. Small bumps can be visible for 24 hours, and mild swelling may persist for up to 5 days. This area often shows the most noticeable improvement due to the baseline thinness of the skin.
Full face:
Most people experience visible bumps for 1–2 days when treated with microinjections. Skin begins to look brighter and smoother around week 2, with further improvement over the following weeks.
Neck and décolletage:
Recovery is similar to the face, with mild swelling and dryness lasting 2–3 days. These areas often feel slightly tight during the initial healing phase.
Hands:
Downtime is minimal. Mild tenderness or swelling may be present for 1–2 days, but visible signs usually resolve quickly.
Scars or targeted areas:
Localised inflammation can last between 2–5 days, depending on the treatment depth. This inflammation triggers the regenerative process and is expected as part of the healing response. Combining Rejuran with other scar treatments such as subcision or injectable volumisers will extend the recovery period.
When will I see results?
The time it takes to see results from Rejuran depends on the treated area, product choice, number of sessions, and your own response to treatment.
Under eyes
- Early improvements in hydration at 2–3 weeks
- Firmer, smoother appearance at 4–6 weeks
Full face
- Skin texture and glow improve from week 2
- Collagen strengthening continues for 3 months
Neck, décolletage, hands
- Results visible from week 3
- Best outcomes typically seen when combined with regular treatments
Lips
- Results visible from week 2
- Results can be optimised by combining with treatments for skin hydration
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Factors that affect downtime
Technique Used
- Microinjections: More bumps and visible downtime, greater collagen stimulation
- Blunt cannula: Minimal surface markings, more comfortable recovery
Lifestyle & aftercare
Following aftercare is critical. Avoid heat, sun, exercise, alcohol, and active skincare products in the first 24–48 hours. For detailed instructions, visit the Rejuran aftercare guide.
When to contact your provider
Seek medical advice if you experience:
- Persistent swelling beyond 5 days
- Significant pain or heat in the area
- Signs of infection
- Allergic reaction symptoms
These are rare but require prompt attention.
Rejuran downtime is usually minimal and manageable, with most visible signs resolving within a few days. While the surface heals quickly, the true transformation happens below the skin as collagen regenerates for weeks. Understanding each stage of recovery helps set realistic expectations and ensures you get the best outcome possible.
Want to know more about Rejuran?
Learn more about Rejuran treatments in our complete Rejuran treatment guide.
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