Detailed Rejuran FAQ: Everything you need to know about treatment, results & safety

About Rejuran

What is Rejuran treatment?

Rejuran is a skin rejuvenation treatment that uses polynucleotides (PNs) derived from salmon DNA to stimulate cellular renewal and improve skin elasticity, tone & texture. It is injected into the skin to target concerns such as fine lines, wrinkles, redness, pigmentation, uneven texture, and loss of firmness, helping your skin look smoother and healthier over time.

What is the difference between Rejuran (Healer), Rejuran I (Eye), and Rejuran S (Scar)?

Rejuran Healer, Rejuran S and Rejuran I have similarities and differences. All contain polynucleotides, but differ in the amount, treatment areas, and gel thickness:

• Rejuran Healer: Versatile, suitable for multiple areas including face, neck, and hands. Comes in a 2mL syringe with 2% PN.
• Rejuran S: Specifically formulated for the treatment of scars. A thicker gel to prevent product spread, Rejuran S comes in a 1mL syringe with 2% PN.
• Rejuran I: Specifically designed for the delicate under-eye area to address dark circles, fine lines, and wrinkles. Some clinics offer Rejuran I treatment for lip rejuvenation. A soft gel that comes in a 1mL syringe with 1% PN.

What is the difference between Rejuran 1 and Rejuran I?

There is no “Rejuran 1”—the “I” in Rejuran I is often misinterpreted as a “1”.

Potential benefits

What are the benefits of Rejuran?

Rejuran works on a cellular level to improve your skin from within. Key potential benefits include:

• Improved hydration and elasticity: Stimulates collagen and hyaluronic-based molecules.
• Reduced fine lines and wrinkles: Smoother, firmer skin over time.
• Enhanced skin texture and tone: Can reduce acne scars, pigmentation, and uneven texture.

Learn more about the top benefits of Rejuran.

Suitability & treatment areas

Who is a good candidate for Rejuran?

Rejuran is an option for individuals who want to rejuvenate their skin from within, improve elasticity, and address natural ageing-related changes in their skin. It may be suitable for people with concerns about:

• Fine lines and wrinkles
• Uneven skin texture or tone
• Dryness or loss of elasticity
• Scars or other skin imperfections
• Those seeking overall skin health and long-term rejuvenation

Your practitioner will assess your skin type, goals, and medical history to determine if Rejuran is the right option for you and create a tailored treatment plan.

What areas can Rejuran treat?

Rejuran can be used on most areas of the face and body where skin rejuvenation is desired. Common treatment areas include:

• Under eyes
• Lips
• Face
• Neck
• Décolletage
• Hands

Clinicians use Rejuran to address a range of concerns across many areas, including delicate ones, with the goal of reducing fine lines, correcting textural issues, and optimising overall skin quality.

Costs

How much does Rejuran cost?

Rejuran costs vary depending on various factors including the treated area, the number of sessions, and clinic location. Typical ranges are:

• Single session: $700–$1,200 on average
• Packages: Multi-session packages typically cost around $2,000-$3000 total and are often recommended for best results.

Cheaper providers may use insufficient product or incorrect administration techniques (such as microneedling), potentially compromising results.

Procedure & treatment process

What is the procedure like?

Rejuran treatment involves a series of steps, beginning with a consultation to determine your suitability and plan your treatment. The PN solution is then injected in small, precise doses into the dermis. The procedure is relatively quick and well-tolerated.

• Pain: Some discomfort is expected with microinjection techniques, but there are various methods and techniques to significantly reduce pain from Rejuran.
• Number of injections: Usually 2–3 sessions spaced a few weeks apart. Each session may involve a series of injections depending on the method: Microionjection approaches require over 40 small injections, while blunt cannula methods may require as little as 2. There are a few things to consider when deciding on the Rejuran injection method.
• Treatment time: Most Rejuran treatments can be completed in 5-30 minutes. The time required depends on the treatment area, extent, method, and skill of the clinicians.

How many injections of Rejuran do I need?

The number of injections varies depending on your skin concerns, treatment area, technique, and desired results. Typically:

• Most patients undergo 2–3 sessions spaced a few weeks apart.
• The treatment area and your practitioner’s assessment determines the number of exact number of injections per session:
  • Microinjection techniques may require over 40 small injections.
  • Blunt cannula techniques may require as little as 2 injections.
• If you wish to sustain results over time, repeat treatments are required.

Can Rejuran Healer be used under the eyes?

While Rejuran Healer is designed for general skin rejuvenation, it is best avoided under the eyes. Although it has a higher concentration of polynucleotides (PNs), its thicker formulation can increase the risk of prolonged swelling or lumps when used with microinjection techniques. Rejuran I (Eye) is preferred for such delicate areas because it is specifically formulated to minimise these risks.

Is Rejuran treatment painful?

Some discomfort is expected, but there are a few methods clinics may use to make the treatment more comfortable:

• Using tiny needles or very fine, blunt cannulas.
• Topical or injectable numbing.
• Mixing Rejuran with local anaesthetic.

Sensitivity varies depending on the treatment area and individual pain tolerance, however most people tolerate the treatment well with appropriate numbing.

Aftercare, downtime & recovery

What is the recovery time for Rejuran?

Recovery from Rejuran is generally quick and straightforward:

• Most patients experience small lumps or bumps at injection sites, which usually resolve within 12–36 hours. Cannula techniques avoid the lumps seen after Rejuran with traditional methods.
• Mild redness or swelling may occur but typically subsides within a few days.
• Minimal downtime means you can usually resume normal activities immediately, though you should avoid things like strenuous exercise and heat exposure for a few days.

What should I expect after treatment?

After a Rejuran session, you may notice:

• Temporary redness, swelling, or small bumps at the injection sites
• Mild soreness or tenderness, which resolves quickly
• Gradual improvement in skin hydration, texture, and elasticity over the following weeks

Your practitioner will provide aftercare instructions to optimise healing and results, and you can learn more about what to expect after Rejuran with our day-by-day Rejuran recovery guide.

What should I avoid after Rejuran?

To ensure the best outcomes, avoid the following and adhere to the Rejuran aftercare for the first few days:

• Strenuous exercise or activities that increase blood flow to the face
• Excessive sun exposure or tanning beds
• Hot showers, saunas, or steam rooms
• Alcohol or smoking, which may slow recovery
• Applying retinol or strong exfoliants on treated areas

You can typically use makeup after 24 hours and sunscreen immediately to protect your skin.

Results

Is Rejuran worth it?

Rejuran is a powerful tool for long-term skin rejuvenation, but results depend on:

• Consistency with recommended treatment sessions
• A holistic approach, including healthy lifestyle and skincare
• Realistic expectations: it optimises skin quality rather than providing a quick-fix transformation

Whether Rejuran is worth it depends on your expectations and commitment; patients who view it as part of an ongoing skin health plan often find it worthwhile. But as with all regenerative-type treatments, outcomes depend on your body’s response to treatment, and can vary.

Does Rejuran actually work?

Rejuran aims to improve skin quality at a cellular level by stimulating collagen and elastin production. Its effectiveness depends on several factors:

• Individual skin condition: Skin texture, elasticity, and existing damage can influence results.
• Treatment consistency: Multiple sessions are often needed to see optimal outcomes.
• Lifestyle and skincare: Healthy habits and proper skincare enhance and maintain results.

While some patients see results for hydration, elasticity, redness, pigmentation and fine lines, results can vary. It works best as part of a comprehensive skin health plan rather than a single quick-fix treatment. Anecdotal evidence shows good satisfaction after Rejuran, but more research is needed to confirm its effectiveness.

How long until results appear, and how long do they last?

• Initial results: Some improvement in skin hydration and texture can be noticed within 2–3 weeks.
• Full results: Cellular renewal continues over several weeks, so optimal effects are visible after 6–8 weeks and a series of sessions.
• Longevity: Effects typically last up to 12 months, depending on skin type, age, and ongoing care.
• Maintenance: Follow-up sessions are required to sustain results long-term. The specific interval and maintenance requirements will vary, and can be discussed during your consultation.

Is Rejuran permanent?

No, Rejuran is not a permanent treatment. It works by stimulating your skin’s natural cellular functions, the results of which gradually decreases over time.

Maintenance sessions are necessary if you wish to preserve results and continue optimising skin quality.

Think of it as a rejuvenation boost rather than a one-time fix.

Risks & side effects

Are there risks or side effects?

Rejuran is generally well-tolerated, but there are potential Rejuran side effects you should be aware of:

• Mild redness, swelling, or bruising at injection sites
• Small bumps or lumps that usually resolve within a few days
• Rarely, allergic reactions or infection

The side effects of Rejuran are the same, regardless of the treatment area and whether you have Rejuran, I, S, or H.

Is Rejuran safe?

Yes, Rejuran is generally safe when it’s done by a trained medical professional.

• It’s made from salmon DNA polynucleotides (PNs), which work well with human skin.
• Most side effects are mild and temporary, like redness, swelling, or small bumps, and usually settle within a few days.

The key is choosing a qualified and experienced medical professional for your treatment. Importantly, as with all treatments there are potential side effects.

Comparisons to other treatments

How does Rejuran compare to other treatments?

Rejuran is different from the usual anti-ageing and cosmetic options but can be used in combination with them. Some treatments Rejuran is often compared to include:

• PRP (Platelet Rich Plasma): Unlike PRP, Rejuran is ready to go and consistent — no blood draw, no spinning in a centrifuge which compromise results.
• Skin boosters: While traditional skin boosters hydrate, Rejuran works deeper at a cellular level to stimulate collagen and improve long-term skin quality. Clinicians can combine them for a holistic result.
• Volumisers: Rejuran doesn’t add volume — it firms, smooths, and revitalises your skin instead. If your concerns are primarily caused by a lack of volume, then Rejuran is unlikely to be the best choice.

Clinicians often combine Rejuran with other treatments, like those that directly target wrinkles and volume loss, for a more complete anti-ageing and skin health plan.

Which is better, PRP or Rejuran?

Both PRP and Rejuran are options for skin rejuvenation. Rejuran is often the preferred option as it doesn’t require a blood draw, and has far fewer variables that may negatively affect the outcome. PRP requires your blood to be taken, which is then spun in a centrifuge, and administered. Each step in the process compromises the PRP quality, meaning it is less effective. Rejuran is a standardised product, is much quicker to administer, and more predictable.

Is Rejuran a volumiser?

No, Rejuran is not a volumiser. While it can improve skin firmness, it does not have any volumising action.

Is Rejuran better than other collagen stimulation methods?

Rejuran is less effective at boosting collagen than primary collagen stimulation methods. However, it has a wider range of benefits, and can also be used in delicate areas (such as around the eyes) where traditional collagen stimulators cannot. The best treatment for you will depend on your individual needs and goals. Each collagen stimulation method has its own unique benefits and may be more suitable for certain conditions.

Is Rejuran the same as wrinkle treatments?

No, Rejuran and wrinkle treatments are not the same. Rejuran promotes cellular renewal, while wrinkle treatments soften lines by relaxing facial muscles.

Want to know more about Rejuran?

Learn more about Rejuran treatments in our complete Rejuran treatment guide.

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