If you’re looking to improve your skin at a deeper, more regenerative level—not just temporarily hydrate or plump it—Rejuran may be the treatment you’ve been waiting for. Known as the “skin healer” treatment, Rejuran uses highly purified Polynucleotide (PN) derived from salmon DNA to actively repair damaged skin, stimulate collagen, and optimise skin structure from within.
Unlike traditional skin boosters that provide hydration alone, Rejuran works on a cellular level to not only reverse age-related skin changes, but also improve long-term skin quality. As a result, it has quickly become one of the most in-demand injectable treatments in Asia. Moreover, it is now gaining popularity in Australia, particularly among patients who are seeking natural, subtle, and long-lasting rejuvenation, as well as those who prefer to invest in preventative treatments.
In this article, we’ll cover everything you need to know about Rejuran—from what it is and how it works to before and after results, cost, downtime, and benefits, as well as guidance on whether it’s the right treatment for you. Additionally, you’ll also gain access to detailed sub-guides focusing on specific areas, including Rejuran for eyes, scars, under-eye wrinkles, and lips.
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What is Rejuran?
Rejuran is a biologically active skin rejuvenation treatment formulated using highly purified Polynucleotides (PN) derived from salmon DNA. These molecules are reported to stimulate cellular repair, increase collagen production, and optimise healthy skin function. Unlike skin boosters that primarily hydrate the skin, Rejuran functions on a regenerative level—repairing the extracellular matrix, improving skin thickness, and optimising long-term skin quality.
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How Rejuran works (The science)
Rejuran works by delivering highly purified Polynucleotides (PN) into the deeper layers of the skin through precise microinjections. These PN molecules act as a biological signal to your skin cells, encouraging them to repair damage, regenerate new tissue, and stimulate the production of collagen and elastin.
The science behind Rejuran
- Fibroblast activation: PN stimulates fibroblast cells, which are responsible for creating collagen, elastin, and the structural foundation of healthy skin.
- Skin healing response: The treatment triggers a natural repair process, aiming to increase skin thickness by reenforcing the extracellular matrix.
- Cellular regeneration: Salmon-derived PN closely resembles human DNA, allowing it to integrate into skin cells, promoting regeneration from within.
- Anti-inflammatory effects: Rejuran may help reduce inflammation and oxidative stress in the skin, optimising overall skin health and resilience.
What this means for you
Through its biological activities, Rejuran aims to:
- Improve skin texture and firmness over time
- Strengthen the skin barrier to better retain moisture
- Repair damaged tissue at a cellular level
- Deliver long-term improvement rather than a temporary cosmetic effect
Rejuran is not a superficial treatment. It encourages cellular renewal in the skin to add structure and strength, making it an adjunct to active skin care, and other clinical treatments designed to promote healthy skin.
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Types of Rejuran
Rejuran is available in several formulations to target specific areas and skin concerns. Each type various primarily in gel thickness, being designed to deliver maximum benefit while maintaining the regenerative properties of PN.
Rejuran Healer (Classic)
- Designed for overall skin rejuvenation and anti-ageing benefits.
- Aims to stimulate collagen production, improve skin texture, and increase elasticity.
- Suitable for full-face treatments, and improving skin on the neck, chest/décolletage, hands, and more.
Rejuran I (Eye)
- A thinner gel, specially formulated for the delicate under-eye area.
- Aims to reduce fine lines, dark circles, and crepiness.
- Preferred for subtle, natural rejuvenation without puffiness.
Rejuran S (Scar)
- A thicker, concentrated gel for repairing acne scars and textural irregularities.
- Promotes collagen remodelling to smooth the skin.
- Often combined with subcision and volume-based treatments for ideal results.
Rejuran skin booster
- Rejuran skin booster is not a standard form of Rejuran.
- It is a customised combination treatment that combines Rejuran with a skin booster.
- Aims to provide hydration and regenerative effects simultaneously.
- Preferable for people looking for both moisture and healing benefits.
Rejuran for lips
Rejuran for lips is a targeted treatment designed to improve lip texture and tone while supporting subtle regenerative effects. Clinicians typically use Rejuran I when treating the lips because it is a softer product.
- It uses microinjections of PN tailored for delicate lip tissue.
- Aims to smooth fine lines, improve lip softness, and support overall lip skin health.
- Preferable for people seeking natural rejuvenation rather than added volume.
How they differ
Purpose
Each formulation is designed for a specific treatment goal and area. Rejuran I targets the delicate under-eye area and may also be used in the lips, Rejuran S is concentrated for scar repair, Rejuran Healer addresses overall facial rejuvenation, and the custom Skin Booster combination focuses on hydration plus regenerative effects. This allows practitioners to select the right treatment based on the patient’s primary concern.
Concentration & consistency
Different formulations contain varying levels of Polynucleotides (PN) and are different thicknesses. Rejuran Healer and Rejuran S have higher PN concentrations to maximise collagen stimulation and skin repair, while Rejuran I provides gentler formulations suitable for sensitive areas. Rejuran S is the thickest product, because it needs to remain localised within the scar, while Rejuran I is the thinnest, because it must spread evenly in the delicate under eye region or lip.
Delivery method
Rejuran can be administered through precise microinjections or a blunt cannula, or microneedling, depending on the area, the desired outcome, and tolerance for discomfort and downtime. A blunt cannula has significantly less pain and recovery (you won’t experience the mosquito-bite like lumps), but may not achieve as significant a result is microinjections. Microneedling-based delivery is the least effective, and is often used in non-medical clinics that are not legally permitted to inject Rejuran into the deeper dermal layers, where it is most effective for collagen stimulation and skin regeneration.
This tailored approach ensures that every patient receives a formulation, concentration, and delivery method customised to their specific skin concerns, delivering natural, targeted, and effective rejuvenation.
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Who is Rejuran for?
Rejuran is suitable for a wide range of patients who want to invest in skin health, texture, and elasticity. It may assist people with concerns about:
- Ageing skin: Individuals noticing early fine lines, wrinkles, or sagging who want to improve skin elasticity and firmness.
- Under-eye concerns: Those with dark circles, hollows, or fine lines under the eyes seeking natural rejuvenation.
- Acne scars and textural issues: Patients looking to smooth scars, reduce pigmentation, and improve overall skin texture.
- Dull or Dehydrated Skin: People wanting hydrated, radiant, and healthy-looking skin.
- Preventative Care: Younger adults aiming to maintain skin quality and slow the signs of aging before they become pronounced.
Rejuran is suitable for all skin types and both men and women. However, it is best administered by qualified medical professionals to ensure optimal results and safety.
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Benefits of Rejuran
Rejuran delivers a unique combination of potential regenerative and cosmetic benefits that aim to optimise both the appearance and health of your skin. Its potential benefits include:
- Skin tightening: Rejuran can provide subtle skin tightening benefits, but they are less effective than traditional collagen stimulating treatments.
- Skin healing and repair: Repairs damaged tissue, reduces fine lines, and improves skin texture.
- Hydration boost: When combined with skin boosters, enhances moisture retention and revitalises dull or dehydrated skin.
- Reduction of scars and pigmentation: Smooths acne scars and reduces uneven skin tone.
- Under-eye rejuvenation: Reduces fine lines and dark circles for a refreshed look.
- Long-term skin quality: Works at a cellular level to strengthen the skin barrier and provide lasting results.
- Subtle and natural results: Improves skin over time without adding volume or creating an artificial look.
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Rejuran before and after results
One of the main reasons patients choose Rejuran is the subtle, natural-looking visible improvement in skin quality over time. Unlike treatments that offer instant but effects that wear off gradually, Rejuran works gradually to repair and rejuvenate skin from within but with longer-lasting effects.
Potential results by area
- Full face: Improved elasticity, smoother texture, and reduction in fine lines.
- Under eyes: Reduced hollows, less crepiness, and diminished dark circles.
- Acne scars: Smoother skin with decreased depth and redness.
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It’s important to note that Rejuran is not a silver bullet, and works best in combination with healthy lifestyle choices, good skin care, and other clinical treatments that target other aspects of the ageing process.
Rejuran treatment process
Understanding what to expect during a Rejuran treatment will help your better prepare should you wish to proceed.
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Consultation
- A qualified practitioner assesses your skin condition and discusses your concerns to determine your suitability.
- Treatment areas and appropriate Rejuran formulation are determined.
- Expected outcomes, number of sessions, cost, and potential side effects are explained.
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Preparation
- A topical numbing cream is applied to ensure patient comfort.
- The skin is thoroughly cleansed to minimise the risk of infection.
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Delivery
- Microinjections: Fine needles deliver many precise PN droplets into targeted areas for maximum effectiveness.
- Blunt Cannula: Used in areas where a faster recovery is desired, though results may be slightly less dramatic.
- Microneedling: Provides surface-level delivery and is less effective than injections or cannula methods, but may be used in non-medical settings.
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Post-treatment care
- A soothing mask or cold compress may be applied to reduce redness or swelling.
- Discussion of aftercare instructions, including activity restrictions and skin maintenance.
Discomfort: Most patients experience discomfort during microinjections. There are various ways to reduce pain from Rejuran, including topical numbing (slightly effective), mixing Rejuran with local anaesthetic (moderately effective), or a blunt cannula technique (highly effective). With good numbing, Rejuran is generally well tolerated.
Duration: Each Rejuran session typically takes 5-30 minutes, depending on the areas and methods used.
Number of session: Most patients require 3 sessions spaced 4 weeks apart for optimal results, but this depends on your needs as determined during your pre-treatment consultation.
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Downtime, aftercare & recovery
Rejuran is non-invasive, and most patients experience mild, temporary effects that resolve quickly. Understanding downtime and proper aftercare requirements helps you better prepare for treatment, and maximise results and comfort.
What to expect after treatment
Immediately after the treatment, you will notice mild redness at the treated areas. Microinjection techniques will also leave a series of small lumps. Swelling and bruising are uncommon, and usually mild, and most people experience mild tenderness once any numbing wears off.
Downtime & recovery
First 24–48 Hours
- A number of small bumps (when microinjection technique is used) that typically subside within 1–2 days
- Minimal bruising may occur in sensitive areas, especially under the eyes
- Avoid touching or massaging the treated area
Day 3–7
- Skin begins natural healing process
- Some redness may linger, but overall appearance normalises
- Resume active skincare routine; avoid harsh clinical treatments
Rejuran aftercare guidelines
- No strenuous exercise for 24 hours
- Avoid alcohol, saunas, hot showers, sun exposure, or heat for 48 hours
- Do not apply makeup for at least 24 hours
- Keep skin hydrated with gentle moisturisers
- Avoid clinical treatments in the treated areas until healed
- Your practitioner may provide additional instructions depending your personal needs.
Recovery expectations
- Most patients can return to normal activities immediately after treatment (keeping in mind the standard aftercare guidelines).
- Visible results develop gradually over 2–4 weeks, however multiple sessions are typically recommended.
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Rejuran cost & price in Australia
Understanding the cost of Rejuran helps people plan their treatments and make informed decisions. Prices vary based on the treatment area, the number of sessions required, and the type of Rejuran used.
Typical Price Ranges
Treatment Area Price per Session (AUD)
Full Face $900 – $1100
Under Eyes $700 – $900
Acne Scars $700 – $900
Neck & Décolletage $900 – $1100
Factors Affecting Cost
- Treatment area & size: Larger areas require more product and time.
- Rejuran formulation: Healer and Scar formulations have higher PN concentration and come in larger sizes, affecting price.
- Number of sessions: Most patients need 3 sessions for optimal results.
- Injector expertise: Experienced, qualified medical professionals may charge higher rates but ensure safety and better outcomes through more precise treatments.
Most clinics offer package pricing when you proceed with more than one session, which can substantially reduce the overall cost. Often, this is to incentivise the completion of a full treatment series, which generally achieves better results.
Cost comparison
Rejuran offers unique regenerative benefits that differ from other injectable treatments. While initial costs may be comparable, the long-term skin quality improvement can provide more value over time, but at the cost of less short term improvement.
Investing in a medically administered Rejuran treatment ensures both safety and effectiveness, maximising the regenerative benefits of the procedure.
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Rejuran side effects & risks
Rejuran is considered a safe and non-invasive treatment when administered by qualified medical professionals. However, like any procedure, mild side effects can occur.
Common, mild Side effects
- Temporary redness or swelling at injection sites
- Small bumps or papules that usually resolve within 24–48 hours with microinjection techniques
- Minor bruising in sensitive areas
- Slight tenderness or itching
Rare or uncommon reactions
- Prolonged redness or swelling
- Localised allergic reaction
- Infection (rare and preventable with proper hygiene and technique)
- Severe, generalised allergic reaction (extremely rare due to high purity and biocompatibility of PN)
Safety considerations
- Rejuran should only be administered only by trained, licensed medical practitioners or registered nurses. Clinics offering microneedling-administered Rejuran often do so because they lack these skilled professionals.
- Treatment with Rejuran must be avoided in patients with active skin infections, flaring autoimmune skin conditions, or known allergies to PN.
- Pregnant or breastfeeding patients should not have Rejuran treatments.
Minimising risks
- A pre-treatment consultation to assess suitability is mandatory
- Strict hygiene and aseptic technique during injections reduces infection risk
- Following aftercare instructions carefully helps speed up healing, and reduce side effects
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Rejuran vs other treatments
Rejuran is different from other cosmetic and skin treatments because it doesn’t primarily focus on surface level correction — rather it works on a cellular level to regenerate and repair the skin. Understanding how it compares to alternatives can help you choose the best combination of approaches for your goals.
Comparison:
- Traditional skin boosters: Focus primarily on skin hydration. Rejuran stimulates collagen and repairs tissue, improving long-term skin quality. They often work well in combination.
- PRP (Platelet-rich plasma): Results vary depending on individual blood quality, and the skill of the clinician preparing the PRP. Rejuran provides standardised PN concentrations for predictable and consistent outcomes.
- Facial volumisers: Add volume to reduce ageing-related facial hollowness and reshape facial contours. Rejuran optimises skin health, texture, and elasticity without altering natural facial structure.
- Laser treatments: Target pigmentation and surface texture by causing controlled microtrauma. Rejuran works beneath the skin, regenerating tissue and stimulating collagen.
Combining Rejuran with other treatments can optimise results, ensuring natural, subtle, and effective rejuvenation.
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Treatment timeline & results expectations
Rejuran works gradually, optimising skin from within. Understanding the treatment schedule and expected outcomes helps manage expectations.
Timeline:
- Immediately after treatment: Minor redness, bumps, or swelling; usually resolves within 24–48 hours.
- 1 week: Slight improvement in hydration and texture.
- 4 weeks: Noticeable firmness and improved skin elasticity.
- 8–12 weeks: Maximum collagen stimulation; skin appears smoother, healthier, and rejuvenated.
Treatment course:
- Most patients require 3 sessions spaced 4 weeks apart for optimal results.
- Changes are gradual, delivering subtle and natural improvements without an artificial appearance.
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Rejuran FAQs
Frequently asked questions
- Is Rejuran safe? Yes, when performed by a qualified medical practitioner, Rejuran has a strong safety profile.
- How long do results last? Full benefits are typically seen after 3 sessions, with maintenance every 6–12 months recommended for ongoing improvement.
- Does it hurt? Mild discomfort is expected with microinjection Rejuran techniques. Using numbing cream, local anaesthetic, or a blunt-cannula method are options to reduce sensation during the treatment.
- Who is it suitable for? Adults seeking to improve skin texture, elasticity, hydration, or reduce scars and under-eye concerns.
- What is the downtime? Minimal; most patients can return to normal activities immediately.
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Rejuran in Australia
Rejuran has become increasingly popular in Australia since it’s introduction, particularly in Sydney and Melbourne, for patients looking for subtle, natural skin rejuvenation and who want to invest in long-term skin health.
Why choose Rejuran in Australia:
- Rejuran I, S and H are listed in the ARTG.
- Rejuran is manufactured by PharmaResearch, a South Korean biotechnology company, and distributed in Australia by K Bridge Medical. For more information, you can visit their official websites: PharmaResearch | K Bridge Medical
- Treatments are personalised based on skin type, age, and specific concerns.
- Experienced medical practitioners and registered nurses can deliver precise and effective treatments.
Cost & access:
- Prices vary depending on the treatment area and formulation, typically ranging from $700-$1100 for a single session in Australia. However most clinics offer multi-session packages where clinically appropriate.
- Most concerns require multiple sessions to achieve optimal and lasting results. During your initial consultation you will be advised on how many sessions you are likely to need.
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