What Rejuran is & its focus
Rejuran is a regenerative skin treatment growing in popularity in Australia that aims to support long-term skin health rather than provide immediate volume or wrinkle correction. Its primary active ingredient, polynucleotides (PN) derived from salmon DNA, is proposed to work at a cellular level to improve skin hydration, elasticity, and texture. By stimulating fibroblasts and supporting tissue repair, Rejuran aims to reinforce the skin’s natural structure over time.
Unlike traditional treatments, Rejuran is primarily preventative. It complements other treatments by gradually optimising skin quality and promoting resilience against environmental and age-related changes.
Different formulations of Rejuran allow tailored approaches to treating different areas and concerns. There are currently three types of Rejuran available in Australia: Rejuran Healer for full-face rejuvenation, Rejuran I for delicate under-eye skin, and Rejuran S for scar treatment. Together, these options provide a versatile toolkit for maintaining healthy skin over the long term.
Treatment course expectations, recovery & timelines
Most patients undergo a series of treatments spaced 3–4 weeks apart, depending on their skin concern and treatment area. Recovery & downtime is generally minimal but varies with different Rejuran injection techniques:
- Microinjections create multiple small injection points, producing temporary bumps or redness that resolve within 24 hours.
- Blunt cannula techniques are less invasive, reduce injection points, have far less discomfort than microinjections, and can be used for larger or sensitive areas, often resulting in less swelling and bruising.
After each session, you may notice subtle improvements in hydration, texture, and firmness. Full effects typically appear after several treatments, with continued improvement over the following months as collagen stimulation and cellular repair processes take effect. Importantly, Rejuran results are more about how your skin feels, rather than how it looks, although there are potential benefits for wrinkles, redness and pigmentation.
For detailed aftercare instructions, see our Rejuran aftercare guide. To understand potential side effects, visit our Rejuran side effects blog.
Realistic expectations & how to assess before/after photos
It’s important for patients to set realistic expectations. Rejuran results are generally subtle and cumulative, focusing on skin health and structure rather than dramatic surface changes.
When evaluating before and after images:
- Look for improvements in skin hydration, texture, brightness, and subtle firmness.
- Ensure lighting, camera angles, and makeup are consistent across photos.
- Avoid images that exaggerate results through filters, heavy editing, or extreme facial expressions.
Clinicians assess improvements using professional tools and touch, evaluating skin elasticity, hydration, and uniformity rather than relying solely on visual comparisons. Understanding these nuances helps patients appreciate the real goals & potential benefits of Rejuran.
Area-specific results & indications
As Rejuran is primarily preventative and optimises skin quality, you’ll soon realise that it is hard to find many before and after photos. Results from Rejuran are just as much related to the quality of your skin (how it feels) as it is about how it looks, and preventative benefits cannot be captured in photos.
Full face rejuvenation
Indications: Loss of elasticity, fine lines, redness, and dullness.
Rejuran applied to the full face can subtly optimise overall skin quality. Patients may notice smoother, firmer skin and a brighter complexion. The effects are gradual, reinforcing skin structure.
What to look for in results photos: Even skin tone, improved texture, subtle plumpness, and softening of fine lines.
Clinician evaluation: Elasticity, hydration, dermal thickness, and texture uniformity are assessed. Photos are secondary to touch and palpation to evaluate tissue improvement accurately.
Before (C) and after (D) 3 sessions of polynucleotide injections for facial redness. Credit: doi:10.1111/srt.70034
Under eye / periocular
Indications: Fine lines, mild dark circles, under-eye texture issues.
Rejuran I is used for the delicate under eye area, because it has a softer gel formulation that spreads evenly. Patients may notice smoother, brighter under-eyes, with reduced texture lines and hydrated skin.
What to look for in results photos: Less pronounced shadowing, more even skin texture, reduced fine lines.
Clinician evaluation: Skin thickness, hydration, and smoothness are evaluated, with careful attention to avoid swelling or lumps.
Before-and-after photos of a Cosmetic Connection patient showing results from one Rejuran I treatment for the under eye.
Before and after 3 sessions of polynucleotides for eye texture wrinkles. Credit: doi.org/10.1080/09546634.2020.1748857
Lips
Indications: Natural hydration, subtle textural improvement, minor regeneration.
Rejuran injections in the lips aim to encourage moisture retention and soft tissue quality. Unlike treatments for lip volume, they do not alter shape or size.
What to look for in results photos: Subtle plumpness, smooth texture, natural colour.
Clinician evaluation: Hydration, suppleness, and improvement in superficial texture are assessed.
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Surgical scars, acne scars & textural concerns
Indications: Mild to moderate surgical scars, acne scarring or rough skin texture.
Rejuran ao,st tp support cellular repair, promoting a smoother skin surface. Patients often notice less noticeable depressions around scarring and improved uniformity in texture. Ideally, Rejuran is used to treat new, healing scars in combination with other methods. Treating mature scars typically requires more aggressive options.
What to look for in results photos: Reduced scar depth, even texture, improved skin tone.
Clinician evaluation: Scar height/depth, dermal thickness, and uniformity of texture & colour are assessed.
Before (A, C, E) -and-after (B, D, F) treatment of surgical scars with laser only (E/F) and laser plus Rejuran (A/B, C/D). Credit: doi: 10.1080/09546634.2024.2426626
Summary & key points
Rejuran is a regenerative treatment that aims to optimise long-term skin health. Its benefits are typically subtle, cumulative, and area-specific, focusing on hydration, texture, and resilience rather than immediate results.
When reviewing before and after photos, look for realistic changes, consistent photo conditions, and professional evaluation criteria. Across all treatment areas—full face, under-eye, lips, scars, neck, décolletage, and hands—Rejuran complements other aesthetic treatments by supporting cellular repair.
Patients who follow a complete treatment course as determined during their consultation and proper aftercare are more likely to notice a gradual, natural improvement in their skin’s quality, reinforcing Rejuran’s emerging evidence as a safe treatment option for skin health and prevention.
Want to know more about Rejuran?
Learn more about Rejuran treatments in our complete Rejuran treatment guide.
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